Letter A

Alpha-synuclein

One in a family of structurally related proteins that are prominently expressed in the central nervous system.

Aggregated alpha-synuclein proteins form brain lesions that are hallmarks of some neurodegenerative diseases (synucleinopathies).

The gene for alpha-synuclein, which is called SNCA, is on chromosome 4q21. One form of hereditary Parkinson disease is due to mutations in SNCA.

Another form of hereditary Parkinson disease is due to a triplication of SNCA.

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