Letter A

Antisense

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In molecular biology, the strand complementary to a coding sequence of a nucleic acid.

<U>Antisense DNA</U> is the non-coding strand complementary to the coding strand in double-stranded DNA.

The antisense strand serves as the template for messenger RNA (mRNA) synthesis.

<U>Antisense RNA</U> is the non-coding strand complementary to a coding sequence of mRNA, a molecule involved in translating genetic instructions into proteins.

Antisense RNA hybridizes with and inactivates mRNA.

<U>Antisense drugs</U> are based on the fact that antisense RNA hybridizes with and inactivates mRNA.

These drugs are short sequences of RNA that attach to mRNA and stop a particular gene from producing the protein for which it holds the recipe.

Antisense drugs are being developed to treat lung cancer, diabetes and diseases such as arthritis and asthma with a major inflammatory component.

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