Letter C

Chargaff rule

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The rule that in DNA there is always equality in quantity between the bases A and T and between the bases G and C.

(A is adenine, T is thymine, G is guanine, and C is cytosine.) Named for the great Austrian-American biochemist Erwin Chargaff (1905-2002) at Columbia University who discovered this rule.

Also known as Chargaff's ratios.

Chargaff later said: 'This observation of complementarity, later called Chargaff's ratios, was essential to the solution of DNA's structure.

In hindsight, the complementary pairing of the nucleotides powerfully suggested that a DNA molecule could break into two parts.

Only complementary bases could form bonds and line up in place in a new DNA strand.

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