Hershey-Chase experiment

An extraordinarily important experiment in 1952 that helped to convince the world that DNA was the genetic material.

Alfred Hershey (1908-1997) and his assistant Martha Chase (1923-2003) at the Cold Spring Harbor Laboratory showed that the DNA, not the protein, of the phage virus contains the phage genes.

After a phage particle attaches to a bacterium, its DNA enters through a tiny hole while its protein coat remains outside.

Key to the success of the experiment was showing that viral infection was unaffected by violent agitation in a kitchen blender (a Waring Blendor) which removed the empty viral protein shells from the bacterial surface.

The Hershey-Chase experiment became known as the 'blender experiment.' Alfred D.

Hershey won a Nobel Prize for his insights into the nature of viruses in 1969, along with Max Delbruck and Salvador Luria.

In a 1997 memoriam to Hersey, James Watson wrote that 'the Hershey-Chase experiment had a much broader impact than most confirmatory announcements and made me ever more certain that finding the three-dimensional structure of DNA was biology's next important objective.

The finding of the double helix by Francis Crick and me came only 11 months after my receipt of a long Hershey letter describing his blender experiment results.'