Letter I

Inheritance, holandric

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Inheritance of genes on the Y chromosome.

Since only males normally have a Y chromosome, Y-linked genes can only be transmitted from father to son.

It has often been said that little is known about specific genes that might be Y-linked (holandric) in their inheritance.

This is no longer true.

As of the year 2000, a number of genes were known to be Y-linked including:</P> > >ASMTY (which stands for acetylserotonin methyltransferase), >TSPY (testis-specific protein), >IL3RAY (interleukin-3 receptor), >SRY (sex-determining region), >TDF (testis determining factor), >ZFY (zinc finger protein), PRKY (protein kinase, Y-linked), >AMGL (amelogenin), >CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome), >ANT3Y (adenine nucleotide translocator-3 on the Y), >AZF2 (azoospermia factor 2), >BPY2 (basic protein on the Y chromosome), >AZF1 (azoospermia factor 1), >DAZ (deleted in azoospermia), >RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1), >RBM2 (RNA binding motif protein 2) and >UTY (ubiquitously transcribed TPR gene on Y chromosome).</LI></UL>

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