Letter I

Interleukin-10

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Abbreviated IL-10. An antiinflammatory and immunosuppressive substance produced within the body.

IL-10 plays a role in the regulation of immune responses.

It is secreted by antigen-presenting cells, promotes the development of immunologic tolerance, and suppresses the production of inflammatory cytokines.

The gene for IL-10 is in chromosome region 1q31-q32. IL-10 modulates acute graft-versus-host disease (GVHD), a major complication in bone marrow transplant.

The presence of a particular variant in the recipient's IL-10 gene is associated with a substantial decrease in the risk of GVHD.

Knowledge of the recipient's IL-10 genotype helps predict the chance of GVHD.

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