Letter M

Mosaic

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An individual or tissue containing two or more types of genetically different cells.

All females are mosaics because of X-chromosome inactivation (lyonization).

Mosaic patterns can affect how genetic disorders are expressed.

For example, about 5 percent of people with Down's syndrome have a mosaic variant, where only some cells have an extra chromosome 21. These individuals have fewer clinical symptoms, are more likely to have a normal IQ, and are less likely to have heart and other problems that can be associated with Down syndrome.

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