Oncogene

<B>1.</B> A gene that played a normal role in the cell as a proto-oncogene and that has been altered by mutation and now may contribute to the growth of a tumor.</P> Some of the more important oncogenes include: > >ras (a signal transduction molecule), >myc (a transcription factor), src (a protein tyrosine kinase), >HER-2/neu, also called erbB-2 (a growth factor receptor), >hTERT (an enzyme involved in DNA replication), and >Bcl-2 (a membrane associated protein that prevents apoptosis).</LI></UL> <B>2.</B> The name of the biomedical journal.

<I>Oncogene</I> is a journal for researchers interested in the molecular biology of malignant change including molecular biologists, cell biologists, oncologists, geneticists and biotechnologists.