Letter P

PPAR

Abbreviation for peroxisome proliferator-activated receptor.

There are 3 known subtypes of PPARs -- PPAR-alpha, PPAR-delta, and PPAR-gamma.

The PPARs are members of the nuclear hormone receptor subfamily of transcription factors.

The gene for PPAR-gamma is in chromosome band 3p25. It regulates the development of adipocytes (fat cells).

PPAR-gamma also influences the prenatal survival of dizygotic (nonidentical) twins.

Twins with the same type of PPAR-gamma may develop at the same pace.

However, when the twins are carrying different versions of PPAR-gamma, one twin may develop at the expense of the other.

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