Superaspirin

A class of drugs that act in certain but not all ways like aspirin.

Also known as Cox-2 inhibitors, these drugs selectively block a specific enzyme called Cox-2. Inhibiting this enzyme impedes the production of the chemical messengers that cause the pain and swelling of arthritis inflammation.</P> The common antiinflammatory drugs (not just aspirin but also, for examples, ibuprofen (ADVIL) and naproxen) all act by blocking the action of two enzymes -- both cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2).</P> > >Cox-1: This enzyme produces certain chemical messengers (called prostaglandins) that ensure the natural mucus lining protecting the stomach.

Because the common antiinflammatory drugs like aspirin block Cox-1, they can reduce the natural stomach protective mucus lining and cause stomach upset, intestinal bleeding, and even ulcers.</LI></UL> > >Cox-2: This enzyme produces different chemical messenger molecules (actually, different types of prostaglandins) that are responsible for inflammation.

When Cox-2 is blocked, inflammation is reduced.

There is no known effect of Cox-2 on the intestinal tract.</LI></UL> The Cox-2 inhibitors represent a new class of drugs that do not affect Cox-1 but do selectively block Cox-2. This selective action provides the benefits of reducing inflammation without irritating the stomach.</P> It is widely expected (and hoped) that superaspirin will of super value to people with arthritis.