Letter T

Tissue plasminogen activator

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(tPA) An enzyme that helps dissolve clots.

TPA is made by the cells lining blood vessels and has also been made in the laboratory.

It is systemic thrombolytic (clot-busting) agent and is used in the treatment of heart attack and stroke.

Activase (alteplase) is a tissue plasminogen activator produced by recombinant DNA technology.

Recombinant tPA is abbreviated r-tPA

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