Y chromosome

The sex chromosome found together with an X chromosome in most normal males.

Once thought to be a genetic wasteland, the Y now is known to contain at least 20 genes, some of them unique to the Y including the male-determining gene and male fitness genes that are active only in the testis and are thought responsible for the formation of sperm.

Other genes on the Y have counterparts on the X chromosome, are active in many body tissues and play crucial 'housekeeping' roles with the cell.</P> A number of specific genes have been Y-linked including: > >ASMTY (which stands for acetylserotonin methyltransferase), >TSPY (testis-specific protein), >IL3RAY (interleukin-3 receptor), >SRY (sex-determining region), >TDF (testis determining factor), >ZFY (zinc finger protein), PRKY (protein kinase, Y-linked), >AMGL (amelogenin), >CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome), >ANT3Y (adenine nucleotide translocator-3 on the Y), >AZF2 (azoospermia factor 2), >BPY2 (basic protein on the Y chromosome), >AZF1 (azoospermia factor 1), >DAZ (deleted in azoospermia), >RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1), >RBM2 (RNA binding motif protein 2) and >UTY (ubiquitously transcribed TPR gene on Y chromosome).</LI></UL> The Y is a useful chromosome for tracking men because it is transmitted unchanged from father to son.

The Y escapes the intergenerational shuffle (recombination) that affects genes on the X chromosome and the remainder of the genome.

All men have essentially the same Y chromosome.

It is thought that in our small ancestral population some men had no children or only daughters, so that some Y chromosomes disappeared until only one was left.

This ubiquitous Y has the same DNA in every man on earth except for the mutation that crops up every millenium and is then inherited by all males descended from that man.