Parkinson disease gene

A gene involved in the causation of Parkinson disease.

There are a number of different autosomal dominant and recessive forms of Parkinson disease.</P> They are called PARK1, PARK2, and so on: > >PARK1 is an autosomal dominant trait and is due to mutation in the alpha-synuclein gene (SNCA) on chromosome 4q21; >PARK2 is an autosomal recessive trait and is due to mutation in the gene encoding parkin on chromosome 6q25.2-q27; >PARK3 is an autosomal dominant trait and is due to a gene on chromosome 2p13; >PARK4 is an autosomal dominant trait and is due to a gene on chromosome 4p15; >PARK5 is an autosomal dominant trait and is due to mutation in the UCHL1 gene on chromosome 4p14; >PARK6 is an autosomal recessive trait and is due to mutation in a gene on chromosome 1p distinct from DJ1; >PARK7 is an autosomal recessive trait and is due to mutation in the DJ1 gene on 1p36; >PARK8 is an autosomal dominant trait and is due to a gene on chromosome 12p11.2-q13.1; >PARK9 is an autosomal recessive trait and is due to a gene on chromosome 1p36; >PARK10 is an autosomal dominant trait and is due to a gene on chromosome 1p; >PARK11 is an autosomal dominant trait and is due to a gene on chromosome 2q.</LI></UL> People in an Iowa family affected with an early-onset autosomal dominant form of Parkinson disease have a triplication of the alpha-synuclein gene (SNCA) on chromosome 4q21. This may be another genetic route to PARK1.